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This approach has been designed to determine the maximum suggested starting dose, even though lower starting doses may also be suitable in some first-in-human clinical trials

And that the drug is part of an overall plan that also includes a healthy diet and exercise

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Even though the effects of SGLT2 inhibitors on blood pressure and weight loss in obese individuals without T2D are identical to those reported in T2D subjects, it is unknown whether such effects can also translate into reduced cardiovascular disease events in this study population